Huntsville is the county seat of Madison County, Alabama. Huntsville is the largest city in northern Alabama in a region of a half-million people, with the city proper having 168,132 residents. Started in 1805 as Twickenham, the city was renamed to 'Huntsville' during the War of 1812, and has grown across nearby hills and along the Tennessee River, adding textile mills, then munitions factories, to become a major city, hosting the NASA Marshall Space Flight Center and Redstone Arsenal. Huntsville apartments for rent comparison page shows most up to date rent information on Huntsville apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.