Guadalupe is a town in Maricopa County, Arizona, United States. According to 2006 Census Bureau estimates, the population of the town is 5,258. The town is nestled between Phoenix and Tempe. It is known as the 'Little Mexico' of the Valley of the Sun and it is home to many religious festivals. The town is a mix of Latinos and Yaqui Indians. Guadalupe apartments for rent comparison page shows most up to date rent information on Guadalupe apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.