San Bernardino is the county seat of San Bernardino County, California, United States. San Bernardino's estimated population, as of 2006, is 201,823. As of 2005, it was the 18th largest city in California, and the 101st largest city in the United States.. It is an anchor city of the Inland Empire. San Bernardino has three major events, the annual Route 66 Rendezvous, a multi-day classic automobile event held in downtown San Bernardino each September, the National Orange Show, held each April/May, and the Western Regional Little League Championships each August. The world's largest fast food chain, McDonald's, began in the city in 1940 by brothers Dick and Mac McDonald. San Bernardino apartments for rent comparison page shows most up to date rent information on San Bernardino apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.