Santee is a city in San Diego County, California, United States. The city is named after Milton Santee, second husband of Jennie Blodgett, whose first husband was George A. Cowles, a ranching pioneer in the San Diego area. As of the 2006, Santee had a population of 54,709. Santee apartments for rent comparison page shows most up to date rent information on Santee apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.