Cape Coral is a city in Lee County, Florida, United States. The population was 102,286 at the 2000 census. According to the U.S Census estimates of 2006, the city had a population of 151,389., making it the largest city in Southwest Florida. As of July 1, 2006, the population estimate for the Cape Coral-Fort Myers metropolitan area was 571,344. Cape Coral apartments for rent comparison page shows most up to date rent information on Cape Coral apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.