Samsula-Spruce Creek is a census-designated place in Volusia County, Florida, United States. The population was 4,877 at the 2000 census. It is principally an agricultural area west of the cities of Port Orange and New Smyrna Beach. Samsula-Spruce Creek apartments for rent comparison page shows most up to date rent information on Samsula-Spruce Creek apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.