Port St. Lucie is a city in St. Lucie County, Florida, United States. The population of Port St. Lucie was 88,769 at the 2000 census. According to the 2006 Census estimates, the city proper had an estimated population of 144,159. Recent estimates from the St. Lucie County of Commerce has the population of the city over 150,000. As of 2005, Port St. Lucie Metropolitan Area Population was 381,033. Port St. Lucie apartments for rent comparison page shows most up to date rent information on Port St. Lucie apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.