St. Lucie is a village in St. Lucie County, Florida, United States. The population was 604 at the 2000 census. As of 2004, the population recorded by the U.S. Census Bureau is 597. St. Lucie apartments for rent comparison page shows most up to date rent information on St. Lucie apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.