Carbondale is a city in Southern Illinois in the midwest United States, is 105 miles or about two hours south of Saint Louis, Missouri. It is known mainly as the site of the main campus of Southern Illinois University. The city is located in Jackson County, Illinois. As of the 2000 census, the city had a total population of 20,681. The city's current mayor is Brad Cole. Carbondale apartments for rent comparison page shows most up to date rent information on Carbondale apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.