Lafayette is a city on the Vermilion River in Lafayette Parish, in the U.S. state of Louisiana. Lafayette is the parish seat. As of the 2000 census, the city had a total population of 110,257; a 2004 census estimate put the metro area's population at 246,160. It is the fourth largest incorporated city in the state. It is the principal city of the Lafayette-Acadiana, LA Combined Statistical Area, which, in 2006, had an estimated total population of 537,947. Lafayette apartments for rent comparison page shows most up to date rent information on Lafayette apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.