Holyoke is a city in Hampden County, Massachusetts, on the banks of the Connecticut River. The population was 39,958 at the 2005 population estimate. The current mayor is Michael Sullivan. It was named after Elizur Holyoke, who explored the area in 1660. Holyoke's nickname is 'The Paper City.' Holyoke apartments for rent comparison page shows most up to date rent information on Holyoke apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.