Pearlington is a census-designated place in Hancock County, Mississippi, United States, on US Highway 90, along the Pearl River, at the Louisiana stateline. It is part of the Gulfport-Biloxi, Mississippi Metropolitan Statistical Area. The population was 1,684 at the 2000 census. On August 29, 2005, at 10 a.m. Hurricane Katrina made landfall just south of Pearlington. Pearlington apartments for rent comparison page shows most up to date rent information on Pearlington apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.