Picayune is the largest city in Pearl River County in Mississippi, a state of the United States of America. The population according to the 2006 census estimate was 20,000. The population was 10,535 at the 2000 census. According to the 2006 census estimates, Pearl River County was one of the 10 fastest growing counties in the United States. Picayune is the business and medical center of Pearl River County. It is within 50 miles of New Orleans, Louisiana and 40 miles from the Mississippi Gulf Coast. The Stennis Space Center is fifteen minutes away. Picayune apartments for rent comparison page shows most up to date rent information on Picayune apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.