Pontotoc is a city in Pontotoc County, Mississippi, United States. Pontotoc is west of the much larger city of Tupelo, Mississippi. The population was 5,253 at the 2000 census. It is the county seat of Pontotoc County. Pontotoc apartments for rent comparison page shows most up to date rent information on Pontotoc apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.