Tupelo is the largest city and county seat within Lee County, Mississippi. It is the eighth largest city in the state of Mississippi, smaller than Meridian, and larger than Olive Branch. The Tupelo area - specifically the nearby village of Blue Springs - was selected during the spring of 2007 as the site for Toyota's eleventh U.S. automobile manufacturing plant. As of the 2000 United States Census, the city's population was 34,211. By 2006, the population was 35,930, with a micropolitan area population of 131,953, encompassing Lee, Pontotoc and Itawamba counties. The city is perhaps best known as the birthplace of Elvis Presley Situated in northeast Mississippi, the city lies between Memphis, Tennessee and Birmingham, Alabama, along U.S. Highway 78 - slated to become Interstate 22 within a few years. Tupelo apartments for rent comparison page shows most up to date rent information on Tupelo apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.