Cape Girardeau is a city located in the county of the same name in Missouri, 115 miles south of Saint Louis. As of the 2000 census, the city population was 35,349. The Cape Girardeau-Jackson, MO-IL Micropolitan Statistical Area embraces Alexander County, Illinois, Bollinger County, Missouri and Cape Girardeau County, Missouri. It is the home of Southeast Missouri State University. The city is not the county seat of Cape Girardeau County as some visitors mistakenly assume. The county seat of Cape Girardeau County is Jackson, Missouri. Cape Girardeau apartments for rent comparison page shows most up to date rent information on Cape Girardeau apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.