Poughkeepsie is a city in New York, U.S.A. and serves as the county seat of Dutchess County, located in the Hudson River Valley midway between New York City and Albany. The name derives from a Native American word, meaning 'the reed covered lodge by the little-water place,' referring to a spring or stream feeding into the Hudson River, south of the present downtown area. Poughkeepsie is known as 'The Queen City of the Hudson.' Poughkeepsie apartments for rent comparison page shows most up to date rent information on Poughkeepsie apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.