Isle of Palms is a city in Charleston County, South Carolina, United States. The population was 4,583 at the 2000 census. Isle of Palms is a barrier island on the South Carolina coast, northeast of Charleston, South Carolina. As defined by the U.S. Census Bureau, Isle of Palms is included within the Charleston-North Charleston Urbanized Area and the larger Charleston-North Charleston Metropolitan Statistical Area. Isle of Palms apartments for rent comparison page shows most up to date rent information on Isle of Palms apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.