Lake Wylieis an unincorporated town in York County, South Carolina, United States. The population was 3,061 at the 2000 census. The town of Lake Wylie, SC derives its name from Lake Wylie, which was named after Dr. W. Gil Wylie in 1960. Lake Wylie apartments for rent comparison page shows most up to date rent information on Lake Wylie apartments and houses. Rent information is obtained from multiple rental sources but we cannot guarantee their accuracy.